Yes, you can pursue Data Science after 12th with Commerce and IP, especially since you're adding Maths from NIOS, which many universities require. Your CUET UG subject choices should include Maths, General Test, and possibly English or IP, depending on the university. Different universities have different eligibility, so always check their official websites. Your stream won't stop you—as long as you have Maths, you're good to go. Just stay consistent with your preparation and aim for good CUET scores.