The GRE is not always required to study Management Information Systems (MIS) in the USA, as admission requirements vary by university. Some programs may waive the GRE requirement based on your academic background, work experience, or other factors. However, submitting a strong GRE score can enhance your application if the program considers it. For personalized advice on whether you need to take the GRE for your specific MIS program and assistance with the application process, you can consult Invicta Career Consultancy, which offers expert support for students planning to study abroad, While there are other options available, hence you can pay a visit to their website (icclearning.com) and  a get consult with them for better guidance. All the best to you.