Correct Answer: Indifference

Solution : The correct option is the second option.

The most appropriate antonym of the word fixation is indifference as fixation refers to a state of being obsessed or excessively focused on a particular thing, idea, or person whereas indifference signifies a lack of interest, concern, or attachment to something. When someone is indifferent, he displays disinterest or apathy rather than being fixated on or overly absorbed in something.

The meanings of the other options are as follows:

• Formulation refers to the development or creation of a plan, system, or method.
• Inclination represents a tendency or preference towards a particular action or belief.
• Reformation refers to the act of making changes or improvements, especially in societal or structural contexts, often linked with reform or improvement in existing conditions.

Hence, the correct answer is indifference.