Download Careers360 App
AIDS and HIV - Causes, Symptoms & Prevention

AIDS and HIV - Causes, Symptoms & Prevention

Edited By Irshad Anwar | Updated on Jul 02, 2025 05:10 PM IST

HIV stands for Human Immunodeficiency Virus, which means that it weakens the immune system. AIDS is also known as Acquired Immunodeficiency Syndrome; this would technically be the last stage of infection from HIV. The topic of HIV is covered in the chapter "Human Health and Diseases" in Biology. This article attempts to sum up HIV and AIDS, their differences, transmission, symptoms, and prevention strategies. The students preparing for exams like CBSE, NEET, AIIMS, JIPMER, and State PMTs, can expect a wide variety of questions based on this topic.

This Story also Contains
  1. What Is HIV?
  2. History Of HIV
  3. Key Characteristics Of HIV
  4. Stages Of HIV
  5. Risk Factors Of Contracting HIV/AIDS
  6. What Is AIDS?
  7. Difference Between AIDS And HIV
  8. What Causes AIDS And HIV?
  9. AIDS And HIV Symptoms
  10. Diagnosis Of HIV
  11. HIV/AIDS Treatment
  12. Prevention Of AIDS And HIV
  13. Tips, Tricks And Strategies To Prepare For AIDS And HIV
  14. Weightage Of HIV And AIDS Topics in Different Entrance Exams
  15. Types Of Questions Asked On The Topic Of HIV And AIDS In Different Exams
  16. Recommended video on HIV

What Is HIV?

HIV is the virus that attacks and destroys CD4 cells, which are a class of T lymphocytes important for the proper functioning of the immune system. Without treatment, HIV will cause many diseases and some cancers to occur over time. HIV is transmitted through certain body fluids, but not through casual contact, water, or air.

Also Read:

History Of HIV

An African chimpanzee species infected humans with HIV. According to studies, HIV may have spread from chimpanzees to humans as early as the late 1800s. Simian immunodeficiency virus (SIV) is the name of the virus that affects chimpanzees. It most likely spread to people when they killed these chimpanzees for food and came into touch with their infected blood. HIV progressively expanded over Africa over many years, then to other regions of the world.

NEET Highest Scoring Chapters & Topics
Know Most Scoring Concepts in NEET 2024 Based on Previous Year Analysis.
Know More

Key Characteristics Of HIV

Read about the key characteristics of HIV:

  • Weakened immune system

  • CD4 cell destroyer

  • Transmitted by some forms of body fluid

  • Is not transmitted using casual contact, water or the atmosphere

Stages Of HIV

  • Stage I - Acute HIV infection - High amount of HIV present in the blood and show Flu-like symptoms.
  • Stage II - Chronic HIV infection - Asymptomatic HIV infection or clinical latency are other names for this stage. The virus is still active. During this period, people may not show any symptoms or get ill, but they can still transmit HIV. Those who adhere to the recommended HIV treatment regimen may never enter Stage 3 (AIDS). This stage could continue for a decade or longer without HIV therapy, or it might move forward very quickly. Hence the incubation period of HIV is 10 years. The person may enter Stage 3 at this stage's conclusion due to an increase in the viral load of HIV in the blood.
  • Stage III - AIDS (Acquired Immunodeficiency Syndrome) - The most advanced and severe stage of HIV.

Risk Factors Of Contracting HIV/AIDS

People are more likely to get HIV when they engage in the following behaviours and circumstances:

  • Sharing contaminated needles, syringes, and other injecting equipment and drug solutions when injecting drugs

  • Engaging in condom-free anal or vaginal sex

  • Having another STI (Sexually Transmitted Infection) like syphilis, herpes, chlamydia, gonorrhoea, and bacterial vaginosis

  • Receiving unsafe injections, blood transfusions, and medical procedures that involve unsterile instruments.

What Is AIDS?

AIDS is the third and final stage of HIV infection. Most people infected with HIV do not develop AIDS. AIDS is diagnosed when the CD4 count of an HIV patient falls below 200 cells per cubic millimetre of blood or when certain opportunistic infections or cancers are present. If untreated, HIV may progress to AIDS in as long as 10 years.

Difference Between AIDS And HIV

There is often a question: "Is AIDS and HIV the same?" The full forms of AIDS and HIV are Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus, respectively. Taking the full form of AIDS and HIV into consideration, we can conclude that both are interdependent, meaning that while HIV is the virus causing the condition, AIDS represents the advanced stage of that infection. Knowing the difference between AIDS and HIV would further enhance awareness.

HIV

AIDS

Human Immunodeficiency Virus

Acquired Immune Deficiency Syndrome

A virus that attacks the immune system

A condition that results from untreated HIV

Can be managed with treatment

Represents advanced stage of HIV infection

Not everyone with HIV will develop AIDS

All individuals with AIDS have contracted HIV

What Causes AIDS And HIV?

HIV is easily passed with the following body fluids. Here are some instances of

Mode of Transmission

Description

Blood

HIV can be transmitted through blood transfusions or sharing needles and syringes.

Breast Milk

An HIV-positive mother can transmit the virus to her child through breastfeeding.

Semen

Unprotected sexual intercourse with an infected individual can lead to transmission via semen.

Vaginal Secretions

Sexual contact involving vaginal secretions from an infected person can also transmit the virus.

Mother-to-Child

HIV can be passed from an infected mother to her child during pregnancy, childbirth, or breastfeeding.

Casual Contact

HIV is NOT transmitted through casual contact such as hugging, shaking hands, or sharing food and water.

AIDS And HIV Symptoms

  • At 2-4 weeks post-exposure, acute manifestations of HIV infection are reported as flu-like symptoms, sometimes cycling on and off.

  • If left untreated, HIV progresses to AIDS, which may exhibit some serious opportunistic infections and cancers in due course.

Diagnosis Of HIV

There are various tests to detect HIV including antibody tests, antibody/antigen tests, and NATs. The duration taken by the above tests for detecting HIV differs.

  • HIV Tests

  • Tests Types

  • Antibody tests

  • Antibody/antigen tests

  • Nucleic acid tests (NAT)

HIV/AIDS Treatment

  • Antiretroviral therapy (ART) manages HIV transmission.

  • ART retards viral replication, allows the healing process of the body but cannot eradicate HIV.

Prevention Of AIDS And HIV

Some measures for the prevention of AIDS and HIV are as follows:

Prevention Strategy

Description

Get an HIV test.

Regular testing allows for early detection and treatment.

Use condoms consistently during sexual activity.

Reduces risk of transmission during sexual intercourse.

Avoid sharing needles or any drug paraphernalia.

Prevents exposure to contaminated blood.

Get tested and treated for STDs.

Reduces the risk of HIV transmission.

Speak with your doctor about prevention medications.

Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) can lower the risk of infection.

The prevention of AIDS and HIV is necessary as it can save a lot of lives that are lost due to the onset of AIDS and HIV.

Tips, Tricks And Strategies To Prepare For AIDS And HIV

Some tricks and tips to revise the topic soon are given below:

AIDS vs. HIV:

  • AIDS is the last stage of HIV (Human Immunodeficiency Virus).

  • Mnemonic: Advanced Infection = AIDS, HIV = Human Virus.

Full Forms:

Write the full form of AIDS and HIV:

  • AIDS: Acquired Immune Deficiency Syndrome

  • HIV: Human Immunodeficiency Virus

Symptoms:

  • Common aids and HIV symptoms are the flu-like signs initially, that turn to severe opportunistic infections in AIDS.

  • Mnemonic: Fever, Rash, Swollen lymph nodes = early signs of HIV.

Progression:

  • If not treated, then the cause of AIDS and HIV progression is the destruction of CD4 cells by HIV which destroys the immune system.

  • Mnemonic: CD4 = Critical cells; their loss leads to AIDS.

Difference Between AIDS and HIV:

  • Understanding the difference between AIDS and HIV is important; not all people with HIV will develop AIDS if treated appropriately.

  • Mnemonic: HIV = Virus, while AIDS = Condition.

Preventive Measures:

  • Aids/HIV-Effective preventives are regular testing, safe sex, and no sharing needles.

  • Mnemonic: Test, Safe sex, and don't share = prevention.

Weightage Of HIV And AIDS Topics in Different Entrance Exams

This table will provide a view of the weightage assigned to the topic of HIV and AIDS in various entrance exams to help students understand and concentrate effectively on their study efforts.

Exam

Weightage (%)

Topics Covered

CBSE

5-10%

Definitions, Symptoms, Transmission, Treatment

NEET

2-5%

Pathophysiology, Prevention, Diagnosis

AIIMS

3-6%

Clinical Features, Management Strategies

JIPMER

4-7%

Epidemiology, Risk Factors

Types Of Questions Asked On The Topic Of HIV And AIDS In Different Exams

When preparing for exams like CBSE, NEET, and others, students can expect various types of questions related to the topic of HIV and AIDS.

Table of Types of Questions

Question Type

Description

Definition Questions

Define HIV and AIDS; explain their full forms.

Symptom Identification

List the aids and HIV symptoms and differentiate between early and late signs.

Transmission Methods

Explain how HIV is transmitted; identify body fluids involved.

Treatment Options

Describe the treatment strategies for managing HIV/AIDS.

Prevention Strategies

Discuss methods for the prevention of AIDS and HIV, including PrEP and PEP.

Differences

Explain the difference between AIDS and HIV; clarify misconceptions.

Risk Factors

Identify behaviours that increase the risk of contracting HIV/AIDS.

This table provides a concise overview of the types of questions that may be asked regarding HIV and AIDS, helping students focus their studies effectively.

Also Read:

Recommended video on HIV


Frequently Asked Questions (FAQs)

1. Does HIV spread by sharing food with the infected person?

No, HIV does not spread by sharing food with the infected person.

2. Are people who get tattoos susceptible to contracting HIV?

Yes, they are susceptible to the sharing of tattoo tools without sanitising them between usage.

3. How many people are infected with HIV in the world?

There are about 38.4 million people in the world who are infected with the virus, HIV.

4. What are the most common symptoms of HIV?

Muscle pain, Fever, Chills, headache and sore throat are the most common symptoms of HIV during the initial stages of infection.

5. Does a person with HIV have rashes?

Skin changes are common among HIV-positive patients. A rash is frequently one of the earliest signs of HIV infection. Typically, an HIV rash looks like a number of little red lesions that are both flat and elevated.

6. What is the difference between HIV and AIDS?
  1. Nature: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system, while AIDS (Acquired Immune Deficiency Syndrome) is a condition that results from untreated HIV infection.
  2. Progression: Not everyone with HIV will develop AIDS, but all individuals with AIDS have contracted HIV.
  3. Management: HIV can be managed with antiretroviral treatment (ART), whereas AIDS indicates severe immune damage and requires more intensive medical care.
7. What is the difference between HIV and AIDS?
HIV (Human Immunodeficiency Virus) is the virus that causes AIDS (Acquired Immunodeficiency Syndrome). HIV is the initial infection that attacks the immune system, while AIDS is the advanced stage of HIV infection when the immune system is severely damaged and the body becomes vulnerable to opportunistic infections.
8. How to prevent HIV and AIDS?
  • Use condoms consistently during sexual activity to reduce transmission risk.
  • Avoid sharing needles or drug paraphernalia to prevent exposure to contaminated blood.
  • Get regular testing for HIV if at risk, allowing for early detection and treatment.
  • Inform sexual partners if you are HIV-positive to encourage testing and awareness.
  • Consider Pre-exposure Prophylaxis (PrEP) if at high risk of infection.
9. How does HIV impact the body's ability to fight other infections?
HIV weakens the immune system by depleting CD4+ T cells, which are crucial for coordinating immune responses. This impairment affects the body's ability to fight off various pathogens, including bacteria, viruses, fungi, and parasites. As a result, HIV-positive individuals become more susceptible to opportunistic infections and certain cancers. Even common infections can become severe or recurrent in people with advanced HIV disease.
10. How does HIV impact the gut-associated lymphoid tissue (GALT)?
HIV has a significant impact on the gut-associated lymphoid tissue (GALT), which contains a large proportion of the body's CD4+ T cells. Early in infection, HIV causes massive depletion of CD4+ T cells in the GALT, leading to a breakdown of the gut mucosal barrier. This can result in microbial translocation (leakage of gut bacteria into the bloodstream), contributing to chronic immune activation and inflammation in HIV-infected individuals.
11. How does HIV affect the aging process?
HIV infection is associated with accelerated aging, even in people with well-controlled HIV. This is thought to be due to chronic inflammation and immune activation caused by the virus. HIV-positive individuals may experience age-related conditions (like cardiovascular disease, bone loss, and cognitive decline) earlier than their HIV-negative peers. This phenomenon is sometimes referred to as "premature aging" or "accelerated aging" in HIV.
12. How does HIV impact the central nervous system?
HIV can enter the central nervous system (CNS) early in infection, crossing the blood-brain barrier. In the CNS, it can infect certain cells like microglia and astrocytes. This can lead to neuroinflammation and neurodegeneration, potentially resulting in HIV-associated neurocognitive disorders (HAND). These disorders can range from mild cognitive impairment to severe dementia, although severe forms are less common with modern antiretroviral therapy.
13. How does HIV impact the cardiovascular system?
HIV infection is associated with an increased risk of cardiovascular disease, even in people with well-controlled virus. This is thought to be due to chronic inflammation and immune activation caused by HIV, as well as side effects of some antiretroviral medications. HIV can affect the heart and blood vessels directly and indirectly, leading to conditions like atherosclerosis, heart attack, and stroke at younger ages compared to the general population.
14. What is the window period in HIV testing?
The window period is the time between potential exposure to HIV and when a test can accurately detect HIV infection. During this period, a person may be infected with HIV but still test negative. The length of the window period varies depending on the type of test used, ranging from about 10 days to 3 months.
15. How does HIV testing work?
HIV testing typically involves detecting antibodies produced by the body in response to HIV infection or detecting the virus itself. Common tests include antibody tests, antigen/antibody combination tests, and nucleic acid tests (NATs). These tests can be performed on blood samples, oral fluids, or urine, depending on the specific test type.
16. What is the concept of "kick and kill" in HIV cure research?
The "kick and kill" strategy is an approach being researched for potentially curing HIV. It involves two steps: 1) "Kick" - using drugs to activate latent HIV in reservoir cells, making the virus visible to the immune system, and 2) "Kill" - eliminating the newly activated virus-infected cells through the body's immune response or other targeted therapies. This strategy aims to eliminate the latent HIV reservoirs that persist even with antiretroviral therapy.
17. What is the role of elite controllers in HIV research?
Elite controllers are a rare group of HIV-positive individuals who can maintain undetectable viral loads without antiretroviral therapy. Studying elite controllers helps researchers understand natural mechanisms of HIV control, which could inform the development of new treatments or vaccines. Factors being investigated include genetic differences, unique immune responses, and characteristics of the infecting virus strain.
18. How does HIV impact the liver?
HIV can affect the liver both directly and indirectly. The virus can infect certain liver cells, leading to inflammation. Additionally, HIV-related immune dysfunction can accelerate liver damage from other causes like hepatitis viruses or alcohol. Some antiretroviral medications can also cause liver toxicity. As a result, liver disease is a significant cause of morbidity and mortality in HIV-positive individuals, especially those co-infected with hepatitis B or C.
19. Why is it difficult to develop a cure for HIV/AIDS?
Developing a cure for HIV/AIDS is challenging because the virus integrates its genetic material into the host cell's DNA and can remain dormant for long periods. Additionally, HIV mutates rapidly, making it difficult for the immune system or drugs to target it effectively. The virus also establishes reservoirs in the body where it can hide from the immune system and antiretroviral drugs.
20. How do antiretroviral drugs work to manage HIV?
Antiretroviral drugs work by interfering with different stages of the HIV life cycle. They can prevent the virus from entering cells, block viral replication, or inhibit the assembly of new virus particles. By suppressing viral replication, these drugs help preserve the immune system and prevent the progression to AIDS.
21. What is meant by the term "undetectable viral load" in HIV treatment?
An undetectable viral load means that the amount of HIV in a person's blood is so low that it cannot be detected by standard tests. This is typically achieved through effective antiretroviral therapy. When a person maintains an undetectable viral load, they have effectively no risk of transmitting HIV to sexual partners, a concept known as "U=U" (Undetectable = Untransmittable).
22. What is the significance of CD4 count in HIV/AIDS management?
CD4 count measures the number of CD4+ T cells in a blood sample. It's a key indicator of immune system health in people with HIV. A normal CD4 count is typically between 500-1,500 cells/mm³. As HIV progresses, the CD4 count drops. A count below 200 cells/mm³ is one of the criteria for an AIDS diagnosis. Monitoring CD4 count helps guide treatment decisions and assess the risk of opportunistic infections.
23. How do HIV mutations contribute to drug resistance?
HIV mutates rapidly due to its error-prone reverse transcriptase enzyme. Some of these mutations can make the virus less susceptible to antiretroviral drugs. When a person is taking antiretroviral therapy, viruses with drug-resistant mutations can survive and replicate, eventually becoming the dominant strain. This is why combination therapy (using multiple drugs) is crucial to prevent the development of drug resistance.
24. What is the concept of "shock and kill" in HIV cure research?
"Shock and kill" is a strategy being researched as a potential cure for HIV. It involves two steps: 1) "Shock" - using drugs to activate latent HIV in reservoir cells, making the virus visible to the immune system, and 2) "Kill" - eliminating the newly activated virus-infected cells through the body's immune response or other targeted therapies. This approach aims to eliminate the latent HIV reservoirs that persist even with antiretroviral therapy.
25. What is the role of dendritic cells in HIV infection and transmission?
Dendritic cells play a complex role in HIV infection. They are among the first cells encountered by HIV during sexual transmission and can capture the virus and transport it to lymph nodes, where it can infect T cells. Some types of dendritic cells can also be directly infected by HIV. However, dendritic cells also play a crucial role in initiating immune responses against HIV. Understanding these dual roles is important for developing strategies to prevent HIV transmission and enhance immune responses against the virus.
26. What is the role of broadly neutralizing antibodies in HIV research?
Broadly neutralizing antibodies (bNAbs) are antibodies capable of neutralizing multiple strains of HIV. Unlike typical antibodies produced in HIV infection, which are often strain-specific, bNAbs can recognize conserved regions of the virus that don't mutate easily. Research into bNAbs is important for developing potential HIV vaccines and new treatment strategies, as they could potentially provide long-lasting protection against diverse HIV strains.
27. How does HIV affect the respiratory system?
HIV can impact the respiratory system in several ways. It increases susceptibility to both common and opportunistic respiratory infections, such as pneumonia and tuberculosis. HIV can also cause direct lung damage and is associated with an increased risk of lung cancer. Chronic lung diseases like COPD are more common in HIV-positive individuals. These effects are due to both the direct impact of the virus and the resulting immune dysfunction.
28. What is the role of autophagy in HIV infection?
Autophagy is a cellular process that degrades and recycles cellular components. In HIV infection, autophagy plays a complex role. On one hand, it can act as an antiviral mechanism, degrading viral components. On the other hand, HIV has evolved mechanisms to subvert autophagy for its own benefit, using it to enhance its replication. Understanding these interactions could lead to new therapeutic approaches targeting autophagy pathways.
29. Can you get HIV from casual contact like hugging or sharing utensils?
No, HIV cannot be transmitted through casual contact. The virus is primarily spread through specific bodily fluids such as blood, semen, vaginal fluids, and breast milk. Everyday activities like hugging, shaking hands, or sharing utensils do not pose a risk for HIV transmission.
30. What are the main routes of HIV transmission?
The main routes of HIV transmission are: unprotected sexual intercourse with an infected person, sharing needles or syringes with an infected person, from an HIV-positive mother to her child during pregnancy, childbirth, or breastfeeding, and through transfusion of contaminated blood or blood products.
31. What is PrEP and how does it prevent HIV infection?
PrEP stands for Pre-Exposure Prophylaxis. It involves taking antiretroviral medications daily by HIV-negative individuals who are at high risk of HIV infection. PrEP works by preventing HIV from establishing a permanent infection if a person is exposed to the virus. When taken consistently, PrEP can reduce the risk of HIV infection by up to 99%.
32. How does mother-to-child transmission of HIV occur and how can it be prevented?
Mother-to-child transmission (also called vertical transmission) can occur during pregnancy, childbirth, or breastfeeding. It can be prevented through a combination of antiretroviral therapy for the mother during pregnancy and after birth, cesarean delivery in some cases, antiretroviral prophylaxis for the newborn, and avoiding breastfeeding when safe alternatives are available.
33. What is the role of CCR5 receptors in HIV infection?
CCR5 is a co-receptor on the surface of certain immune cells, particularly CD4+ T cells. HIV uses this receptor, along with the CD4 receptor, to enter and infect cells. Some people have a genetic mutation (CCR5-Δ32) that results in the absence of CCR5 receptors, making them highly resistant to HIV infection. This discovery has led to research into CCR5 inhibitors as a potential HIV treatment and prevention strategy.
34. How does HIV affect the endocrine system?
HIV can impact various endocrine glands and hormones. It's associated with thyroid dysfunction, adrenal insufficiency, and alterations in growth hormone and sex hormone levels. These effects can be due to direct viral impact, opportunistic infections, or side effects of antiretroviral therapy. Endocrine disorders in HIV can contribute to metabolic complications, body composition changes, and reduced quality of life.
35. How does HIV affect bone health?
HIV infection and certain antiretroviral medications can negatively impact bone health, leading to decreased bone mineral density and an increased risk of osteoporosis and fractures. This is thought to be due to chronic inflammation, alterations in vitamin D metabolism, and direct effects of the virus on bone-forming cells. Regular monitoring of bone health and interventions like calcium and vitamin D supplementation are often recommended for HIV-positive individuals.
36. How does HIV affect pregnancy and fetal development?
HIV can impact pregnancy in several ways. It increases the risk of complications like preterm birth, low birth weight, and stillbirth. Without proper treatment, there's a significant risk of mother-to-child transmission. HIV can also affect fetal development, potentially leading to growth restriction. However, with appropriate antiretroviral therapy and prenatal care, HIV-positive women can have healthy pregnancies and give birth to HIV-negative babies.
37. What are opportunistic infections in the context of AIDS?
Opportunistic infections are infections that occur more frequently or are more severe in people with weakened immune systems, such as those with AIDS. These infections are caused by pathogens that typically don't cause disease in people with healthy immune systems. Common examples include Pneumocystis pneumonia, Kaposi's sarcoma, and Candidiasis.
38. What is the concept of "post-treatment controllers" in HIV research?
Post-treatment controllers are individuals who maintain undetectable viral loads for an extended period after stopping antiretroviral therapy. Unlike elite controllers, these individuals initially required treatment to suppress the virus. Studying post-treatment controllers helps researchers understand factors that contribute to long-term viral control and could inform strategies for achieving drug-free remission of HIV.
39. What is the difference between HIV-1 and HIV-2?
HIV-1 and HIV-2 are two distinct types of HIV. HIV-1 is more virulent, more easily transmitted, and is the cause of the majority of HIV infections globally. HIV-2 is less transmissible and is mainly found in West Africa. HIV-2 generally progresses more slowly and is less likely to lead to AIDS, but it can still cause immune suppression and opportunistic infections if left untreated.
40. How does HIV weaken the immune system?
HIV specifically targets and destroys CD4+ T cells, which are crucial for coordinating the immune response. As these cells are destroyed, the body's ability to fight off infections and diseases progressively declines, leading to a weakened immune system.
41. How does HIV replicate inside human cells?
HIV replication involves several steps: 1) The virus attaches to and enters a host cell, 2) Its RNA is converted to DNA by reverse transcriptase, 3) The viral DNA is integrated into the host cell's DNA, 4) The host cell produces viral RNA and proteins, 5) New virus particles are assembled, and 6) The new viruses bud off from the host cell to infect other cells.
42. How does HIV evade the immune system?
HIV evades the immune system through several mechanisms: rapid mutation that allows it to escape recognition, destruction of key immune cells (CD4+ T cells), establishment of latent reservoirs where it can hide, and interference with the body's interferon response. These strategies make it difficult for the immune system to mount an effective defense against the virus.
43. What is the significance of Langerhans cells in HIV transmission?
Langerhans cells are a type of dendritic cell found in the skin and mucous membranes. They play a complex role in HIV transmission. Initially, it was thought that these cells might help prevent HIV infection by capturing and destroying the virus. However, research has shown that HIV can also infect Langerhans cells and use them to spread to T cells. Understanding the role of Langerhans cells is important for developing strategies to prevent sexual transmission of HIV.
44. What is the role of cytokine storms in HIV infection?
Cytokine storms, which are excessive or uncontrolled releases of pro-inflammatory cytokines, can occur in HIV infection, particularly during acute infection or AIDS. These storms contribute to the massive depletion of CD4+ T cells and can cause severe inflammation throughout the body. Understanding and potentially modulating these cytokine responses is an area of research for improving HIV treatment and reducing HIV-associated inflammation.
45. What is the concept of "functional cure" in HIV research?
A functional cure for HIV refers to a state where the virus is not eliminated from the body, but is controlled to the point where it causes no health problems and cannot be transmitted, without the need for ongoing antiretroviral therapy. This is different from a "sterilizing cure," which would completely eliminate the virus from the body. Research into functional cures focuses on strategies to achieve long-term viral suppression without daily medication.
46. How does HIV impact the kidneys?
HIV can affect the kidneys both directly and indirectly. HIV-associated nephropathy (HIVAN) is a kidney disease caused by direct infection of kidney cells by HIV. Additionally, long-term inflammation, immune complex deposition, and certain antiretroviral medications can also damage the kidneys. As a result, kidney disease is more common in HIV-positive individuals, necessitating regular monitoring of kidney function.

Articles

Back to top